氨基喹啉导向、钴催化的磺酰胺sp C-H键羰基化反应。
Aminoquinoline-directed, cobalt-catalyzed carbonylation of sulfonamide sp C-H bonds.
作者信息
Nguyen Tung Thanh, Grigorjeva Liene, Daugulis Olafs
机构信息
Department of Chemistry, University of Houston, Houston, TX 77204-5003, USA.
出版信息
Chem Commun (Camb). 2017 May 4;53(37):5136-5138. doi: 10.1039/c7cc02062g.
Abstract
We report a method for cobalt-catalyzed, aminoquinoline-directed sp C-H bond carbonylation of sulfonamides. The reactions proceed in a dichloroethane solvent, and employ diisopropyl azodicarboxylate as a carbon monoxide source, Mn(OAc) as a cooxidant and potassium pivalate as a base. Halogen, ester, and amide functionalities are compatible with the reaction conditions. This method allows for a short and efficient synthesis of saccharin derivatives.
摘要
我们报道了一种钴催化、氨基喹啉导向的磺酰胺sp C-H键羰基化反应方法。该反应在二氯乙烷溶剂中进行，使用偶氮二羧酸二异丙酯作为一氧化碳源、醋酸锰作为共氧化剂、特戊酸钾作为碱。卤素、酯和酰胺官能团与反应条件兼容。该方法可实现糖精衍生物的短程高效合成。
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