Latvian Institute of Organic Synthesis, Aizkraukles Street 21, Riga LV-1006, Latvia.
Org Lett. 2021 Apr 2;23(7):2748-2753. doi: 10.1021/acs.orglett.1c00660. Epub 2021 Mar 16.
Herein we report an efficient protocol for the C(sp)-H carbonylation of amino acid derivatives based on an inexpensive cobalt(II) salt catalyst. Carbonylation was accomplished using picolinamide as a traceless directing group, CO (1 atm) as the carbonyl source, and Co(dpm) as the catalyst. A broad range of phenylalanine derivatives bearing diverse functional groups were tolerated. Moreover, the method can be successfully applied for the C(sp)-H carbonylation of short peptides thereby allowing access for peptide late-stage carbonylation.
在此，我们报告了一种基于廉价钴(II)盐催化剂的氨基酸衍生物 C(sp)-H 羰基化的有效方法。羰基化反应使用吡啶甲酰胺作为无痕迹导向基团，CO（1 大气压）作为羰基源，Co(dpm)作为催化剂来完成。该方法容忍了带有各种官能团的广泛的苯丙氨酸衍生物。此外，该方法还可以成功地应用于短肽的 C(sp)-H 羰基化，从而可以实现肽的后期羰基化。
