重症肌无力患者进行体育锻炼是安全的，且能改善神经肌肉参数和基于身体机能的指标：一项初步研究。

Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance-based measures: A pilot study.

作者信息

Westerberg Elisabet, Molin Carl Johan, Lindblad Ida, Emtner Margareta, Punga Anna Rostedt

机构信息

Department of Clinical Neurophysiology, Department of Neuroscience, Uppsala University, Box 593, BMC, SE-75124, Sweden.

Department of Neurology, Ryhov County Hospital, Jönköping, Sweden.

出版信息

Muscle Nerve. 2017 Aug;56(2):207-214. doi: 10.1002/mus.25493. Epub 2017 Apr 2.

DOI:10.1002/mus.25493

PMID:27935072

Abstract

INTRODUCTION

Due to the shortage of exercise-related research in Myasthenia Gravis (MG), there are no consensus guidelines on physical exercise for MG patients.

METHODS

In this prospective pilot study, 10 MG patients with mild disease performed supervised aerobic and resistance training twice weekly for 12 weeks. The Myasthenia Gravis Composite (MGC) score, compound motor action potential (CMAP), repetitive nerve stimulation, muscle force, physical performance-based measures, serum levels of interleukin-6, muscle enzymes, and immuno-microRNAs miR-150-5p and miR-21-5p were assessed before and after the training period.

RESULTS

Physical exercise was well tolerated, and the MGC score was unchanged. Muscle resistance weights and CMAP amplitudes increased for biceps brachii and rectus femoris muscles, and physical performance-based measures improved. Muscle enzymes remained normal, whereas disease-specific microRNAs miR-150-5p and miR-21-5p were reduced after the training period.

CONCLUSIONS

We propose that general recommendations regarding physical exercise can be applied safely to well-regulated MG patients. Muscle Nerve 56: 207-214, 2017.

摘要

引言

由于重症肌无力（MG）相关运动研究的匮乏，目前尚无针对MG患者体育锻炼的共识性指南。

方法

在这项前瞻性试点研究中，10例轻度疾病的MG患者每周接受两次有监督的有氧运动和抗阻训练，为期12周。在训练期前后评估重症肌无力综合（MGC）评分、复合运动动作电位（CMAP）、重复神经电刺激、肌肉力量、基于身体表现的指标、白细胞介素-6血清水平、肌肉酶以及免疫微小RNA miR-150-5p和miR-21-5p。