重症肌无力患者的运动：有氧运动和抗阻训练的可行性研究
Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training.
作者信息
Rahbek Martin Amadeus, Mikkelsen Erik Elgaard, Overgaard Kristian, Vinge Lotte, Andersen Henning, Dalgas Ulrik
机构信息
Section for Sport Science, Department of Public Health, Aarhus University, Denmark, Dalgas Avenue 4, 8000, Aarhus C, Denmark.
Department of Neurology, Aarhus University Hospital, Noerrebrogade, 44, 8000 Aarhus C, Denmark.
出版信息
Muscle Nerve. 2017 Oct;56(4):700-709. doi: 10.1002/mus.25552. Epub 2017 Mar 24.
INTRODUCTION
It has not been established whether progressive resistance training (PRT) and aerobic training (AT) are feasible and efficient in myasthenia gravis (MG).
METHODS
Fifteen subjects with generalized MG (Myasthenia Gravis Foundation of America (MGFA) clinical classification II-IV) were randomly assigned to 20 training sessions during 8 weeks of either PRT or AT. Feasibility was evaluated based on adherence, drop-out rate, adverse events, and Quantitative Myasthenia Gravis (QMG) score.
RESULTS
Twelve subjects (MGFA II, n = 11; MGFA III, n=1) completed the intervention with a mean adherence of 95 % ± 8. One dropout (PRT) could potentially be related to PRT. Both groups reported adverse events, including bulbar symptoms (n = 2) and increased fatigue (n = 3), but no change in QMG score was observed in either group. The PRT group showed increases in maximal strength and functional capacity.
CONCLUSIONS
Eight weeks of moderate to high intensity AT and PRT were feasible for most patients with mild MG. Maximal strength and functional capacity increased in the PRT group. Muscle Nerve 56: 700-709, 2017.
引言
目前尚未确定渐进性抗阻训练（PRT）和有氧训练（AT）在重症肌无力（MG）患者中是否可行且有效。
方法
15名美国重症肌无力基金会（MGFA）临床分级为II-IV级的全身型MG患者被随机分配，在8周内进行20次PRT或AT训练。基于依从性、退出率、不良事件和重症肌无力定量评分（QMG）对可行性进行评估。
结果
12名患者（MGFA II级，n = 11；MGFA III级，n = 1）完成了干预，平均依从率为95%±8%。1名退出者（PRT组）可能与PRT有关。两组均报告了不良事件，包括延髓症状（n = 2）和疲劳加重（n = 3），但两组的QMG评分均未观察到变化。PRT组的最大力量和功能能力有所增加。
结论
对于大多数轻度MG患者，进行8周的中高强度AT和PRT是可行的。PRT组的最大力量和功能能力有所提高。《肌肉与神经》56: 700 - 709, 2017年。
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