Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran.
Int J Mol Sci. 2021 Nov 30;22(23):12964. doi: 10.3390/ijms222312964.
Myasthenia gravis (MG) is an autoimmune condition related to autoantibodies against certain proteins in the postsynaptic membranes in the neuromuscular junction. This disorder has a multifactorial inheritance. The connection between environmental and genetic factors can be established by epigenetic factors, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). XLOC_003810, SNHG16, IFNG-AS1, and MALAT-1 are among the lncRNAs with a possible role in the pathoetiology of MG. Moreover, miR-150-5p, miR-155, miR-146a-5p, miR-20b, miR-21-5p, miR-126, let-7a-5p, and let-7f-5p are among miRNAs whose roles in the pathogenesis of MG has been assessed. In the current review, we summarize the impact of miRNAs and lncRNAs in the development or progression of MG.
重症肌无力(MG)是一种与神经肌肉接头后膜上某些蛋白的自身抗体有关的自身免疫性疾病。这种疾病具有多因子遗传。环境和遗传因素之间的联系可以通过表观遗传因素来建立,例如 microRNAs(miRNAs)和长链非编码 RNAs(lncRNAs)。XLOC_003810、SNHG16、IFNG-AS1 和 MALAT-1 是在 MG 病理生理学中可能具有作用的 lncRNAs 之一。此外,miR-150-5p、miR-155、miR-146a-5p、miR-20b、miR-21-5p、miR-126、let-7a-5p 和 let-7f-5p 是已经评估了其在 MG 发病机制中的作用的 miRNAs 之一。在本综述中,我们总结了 miRNAs 和 lncRNAs 在 MG 发展或进展中的作用。