中国陕西省妇女高危型人乳头瘤病毒感染的流行情况：一项基于医院的调查。
Prevalence of high-risk human papillomavirus infection among women in Shaanxi province of China: A hospital-based investigation.
机构信息
Department of Gynecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Department of Gynecology and Obstetrics, The Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi, China.
出版信息
J Med Virol. 2017 Jul;89(7):1281-1286. doi: 10.1002/jmv.24748. Epub 2016 Dec 23.
This study aimed to investigate the characteristics of female high-risk human papillomavirus (HR-HPV) infection in Shaanxi province of China. A total of 14 111 women were enrolled for HPV genotyping test, and a cytology, and/or cervix biopsy were performed in partial women. Of these women, the HPV infection rate was 30.21%, and 26.73% were caused by HR-HPV. The most common HR-HPV genotypes were HPV-16, HPV-58, HPV-52, HPV-18, and HPV-31. The prevalence of HR-HPV among women older than 50 years was significantly higher than the other groups (P < 0.05). The main carcinogenic genotypes were HPV-16, HPV-18, HPV-58, HPV-52, and HPV-31. HPV-16 and HPV-18 combined caused 80.79% of cervical cancer cases. The infection with multiple HR-HPVs was not a risk factor for cervical lesions. In conclusion, HPV infection was common among women in Shaanxi province. Women older than 50 years were a high-risk group for HR-HPV infection and cervical cancer. HPV-16 and HPV-18 were the main carcinogenic genotypes in this region.
本研究旨在探讨中国陕西省女性高危型人乳头瘤病毒（HR-HPV）感染的特征。共招募了 14111 名女性进行 HPV 基因分型检测，部分女性同时进行细胞学和/或宫颈活检。这些女性中 HPV 感染率为 30.21%，其中 26.73%由 HR-HPV 引起。最常见的 HR-HPV 基因型为 HPV-16、HPV-58、HPV-52、HPV-18 和 HPV-31。50 岁以上女性的 HR-HPV 感染率明显高于其他组（P<0.05）。主要致癌基因型为 HPV-16、HPV-18、HPV-58、HPV-52 和 HPV-31。HPV-16 和 HPV-18 联合导致 80.79%的宫颈癌病例。感染多种 HR-HPV 不是宫颈病变的危险因素。总之，HPV 感染在中国陕西省女性中很常见。50 岁以上的女性是 HR-HPV 感染和宫颈癌的高危人群。HPV-16 和 HPV-18 是该地区的主要致癌基因型。
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