10867名中国汉族女性中人乳头瘤病毒的流行情况与分布

The prevalence and distribution of human papillomavirus among 10,867 Chinese Han women.

作者信息

Guo Chunlei, Du Hui, Belinson Jerome L, Wang Chun, Huang Xia, Qu Xinfeng, Wu Ruifang

机构信息

Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, No. 1120, Lianhua Road, Shenzhen, Guangdong, 518036, PR China.

Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological Diseases, Shenzhen, Guangdong, PR China.

出版信息

Infect Agent Cancer. 2021 Mar 25;16(1):21. doi: 10.1186/s13027-021-00360-9.

OBJECTIVE

To assess the prevalence and distribution of HPV genotypes among Chinese Han women, and to explore the risk of high-grade cervical lesions associated with individual hr-HPV genotypes.

METHODS

Genotyping and histopathology data from the Chinese Multi-Center Screening Trial (CHIMUST) and its pilot screening trial, from 6 regions across mainland China, were re-analyzed. The data from physician- and self-collected samples from 10,867 Chinese Han women (ages 30-69) were used to determine the prevalence and distribution of hr-HPV and to explore the risk association between hr-HPV genotypes and precancerous lesions.

RESULTS

9.2% of the study population tested hr-HPV positive in physician-collected sample. The prevalence varied regionally from the lowest in Guangdong (6.3%) to the highest in Inner Mongolia (13.0%). The most prevalent genotypes found were HPV-52 (21.7%), HPV-16 (19.2%), HPV-58 (15.0%), HPV-39 (8.9%), and HPV-51 (8.2%). The overall odds ratios for CIN2+ and CIN3+ for the presence of HPV-16 was 58.6 (95% CI 39.2-87.5) and, 91.6 (95%CI 54.3-154.6), respectively and remained the highest odds ratio for CIN3+ in all 6 regions.

CONCLUSION

Geographical variation exists in the prevalence and distribution of hr-HPV in mainland China. HPV-16/52/58 were the most prevalent genotypes, and HPV-16 had the highest risk for high-grade cervical lesions.

TRIAL REGISTRATION

CHIMUST, Registration number: ChiCTR-EOC-16008456 . Registered 11 May 2016.

目的

评估中国汉族女性人乳头瘤病毒（HPV）基因型的流行情况和分布，并探讨与个体高危型HPV基因型相关的高级别宫颈病变风险。

方法

对来自中国大陆6个地区的中国多中心筛查试验（CHIMUST）及其试点筛查试验的基因分型和组织病理学数据进行重新分析。使用来自10867名中国汉族女性（年龄30 - 69岁）由医生采集和自我采集样本的数据，以确定高危型HPV的流行情况和分布，并探讨高危型HPV基因型与癌前病变之间的风险关联。

结果

在医生采集的样本中，9.2%的研究人群检测出高危型HPV呈阳性。患病率存在地区差异，从广东的最低值（6.3%）到内蒙古的最高值（13.0%）。发现最常见的基因型为HPV - 52（21.7%）、HPV - 16（19.2%）、HPV - 58（15.0%）、HPV - 39（8.9%）和HPV - 51（8.2%）。HPV - 16阳性者发生CIN2 +和CIN3 +的总体比值比分别为58.6（95%可信区间39.2 - 87.5）和91.6（95%可信区间54.3 - 154.6），并且在所有6个地区中，HPV - 16阳性者发生CIN3 +的比值比始终最高。