[下肢缺血模型实验中肌肉注射干细胞/祖细胞的疗效]
[Efficacy of intramuscular administration of stem/progenitor cells in experiment on the model of lower limb ischaemia].
作者信息
Poveshchenko O V, Lykov A P, Bondarenko N A, Kim I I, Yankaite E V, Kazakov O V, Surovtseva M A, Bgatova N P, Karpenko A A, Pokushalov E A, Konenkov V I
机构信息
Laboratory of Cell Technologies, Scientific Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
出版信息
Angiol Sosud Khir. 2016;22(4):51-54.
An experimental model of lower limb ischaemia induced by ligation of the femoral artery in CBA-line mail rats was used to study efficacy and effect of intramuscular administration of autologous bone-marrow stem/progenitor cells on the process of angiogenesis. Based on the findings of laser Doppler flowmetry it was shown that administration of autologous stem/progenitor cells promotes acceleration of the processes of neoangiogenesis, which was confirmed by the results of histological study.
利用结扎CBA系雄性大鼠股动脉诱导下肢缺血的实验模型，研究自体骨髓干/祖细胞肌肉注射对血管生成过程的疗效和作用。基于激光多普勒血流仪的检测结果表明，自体干/祖细胞的注射促进了新血管生成过程的加速，这一点得到了组织学研究结果的证实。
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