Yusuf Helmy, Kett Vicky
a School of Pharmacy, Queen's University of Belfast , Belfast , Antrim , UK.
b School of Pharmacy, Queen's University of Belfast , Belfast , Antrim , UK.
Hum Vaccin Immunother. 2017 Jan 2;13(1):34-45. doi: 10.1080/21645515.2016.1239668. Epub 2016 Dec 9.
Nasal delivery offers many benefits over traditional approaches to vaccine administration. These include ease of administration without needles that reduces issues associated with needlestick injuries and disposal. Additionally, this route offers easy access to a key part of the immune system that can stimulate other mucosal sites throughout the body. Increased acceptance of nasal vaccine products in both adults and children has led to a burgeoning pipeline of nasal delivery technology. Key challenges and opportunities for the future will include translating in vivo data to clinical outcomes. Particular focus should be brought to designing delivery strategies that take into account the broad range of diseases, populations and healthcare delivery settings that stand to benefit from this unique mucosal route.
与传统的疫苗接种方法相比，鼻腔给药具有许多优势。这些优势包括无需打针即可轻松给药，减少了与针刺伤和处置相关的问题。此外，这种给药途径可轻松接触免疫系统的关键部分，从而刺激全身其他黏膜部位。成人和儿童对鼻腔疫苗产品的接受度不断提高，推动了鼻腔给药技术的蓬勃发展。未来的主要挑战和机遇将包括将体内数据转化为临床结果。应特别关注设计给药策略，要考虑到受益于这种独特黏膜给药途径的广泛疾病、人群和医疗保健环境。
