通过芳基重氮盐、腈和炔的三组分级联环化反应合成喹啉。
Synthesis of Quinolines through Three-Component Cascade Annulation of Aryl Diazonium Salts, Nitriles, and Alkynes.
机构信息
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023, China.
Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University , Nanjing 210008, China.
出版信息
J Org Chem. 2017 Jan 6;82(1):770-775. doi: 10.1021/acs.joc.6b02509. Epub 2016 Dec 22.
An efficient and rapid synthesis of multiply substituted quinolines is described. This method is enabled by a three-component cascade annulation of readily available aryl diazonium salts, nitriles, and alkynes. This reaction is catalyst- and additive-free. Various aryl diazonium salts, nitriles, and alkynes can participate in this transformation, and the yields are up to 83%.
描述了一种高效、快速合成多取代喹啉的方法。该方法通过易得的芳基重氮盐、腈和炔的三组分级联环化来实现。该反应无需催化剂和添加剂。各种芳基重氮盐、腈和炔都可以参与这种转化，产率高达 83%。
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