Stoff D M, Friedman E, Pollock L, Vitiello B, Kendall P C, Bridger W H
J Am Acad Child Adolesc Psychiatry. 1989 Sep;28(5):754-60. doi: 10.1097/00004583-198909000-00018.
Platelet monoamine oxidase (MAO) activity was measured in 32 drug-free prepubertal boys with externalizing symptoms of disruptive behavior disorders and 47 boys with no DSM-III-R diagnoses, and correlated to questionnaire and laboratory performance measures of impulsivity. A subgroup of boys with high MAO activity exhibited significantly poorer performance (i.e., more impulsivity) than a subgroup of low MAO activity on laboratory tasks requiring response inhibition. High MAO patients were more impulsive than high MAO controls on some performance tasks and elevated platelet MAO was unrelated to personality questionnaire measures of impulsivity or to patient status. These data suggest that biological markers such as MAO activity may correlate better with performance than clinical questionnaire measures. Abnormally high platelet MAO activity may not be sufficient to produce externalizing symptoms in children, perhaps interacting with an underlying behavioral dimension of impulsivity.
对32名无用药史的青春期前有破坏性行为障碍外化症状的男孩和47名无DSM-III-R诊断的男孩进行了血小板单胺氧化酶（MAO）活性测定，并将其与冲动性的问卷及实验室表现指标进行关联分析。在需要反应抑制的实验室任务中，MAO活性高的男孩亚组表现明显比MAO活性低的男孩亚组差（即更冲动）。在一些表现任务中，高MAO患者比高MAO对照更冲动，且血小板MAO升高与冲动性的人格问卷指标或患者状态无关。这些数据表明，诸如MAO活性等生物学标志物可能比临床问卷指标与表现的相关性更好。血小板MAO活性异常升高可能不足以在儿童中产生外化症状，也许与潜在的冲动性行为维度相互作用。
