Díaz-Marsá M, Carrasco J L, Hollander E, César J, Saiz-Ruiz J
Department of Psychiatry, Fundación Jiménez Díaz Hospital, Madrid, Spain.
Acta Psychiatr Scand. 2000 Mar;101(3):226-30.
To study if platelet MAO activity, previously described as a serotonergic index, is modified in a sample of pure restrictive anorectic patients.
Twenty-five female patients with DSM-IV anorexia nervosa restricting type were studied and compared with 30 healthy female controls. Platelet MAO activity was measured by isotopic methods using C-14 benzylamine. Impulsive personality features were measured with specific rating scales and temperament studied with Cloninger's TCI.
Platelet MAO activity was significantly lower (4.3+2.7 nmol/h/ 108 platelets) in the anorectic patients than in the control group (6.7+2.8) (P<0.01). Platelet MAO was inversely correlated with scores on impulsivity scales and positively correlated with the dimension 'persistence' of Cloninger's TCI.
Platelet MAO activity is lowered in a group of patients with anorexia nervosa and might involve some dysfunction in the regulation of impulse control.
研究在单纯性限制型神经性厌食症患者样本中，先前被描述为血清素能指标的血小板单胺氧化酶（MAO）活性是否发生改变。
对25名患有DSM-IV神经性厌食症限制型的女性患者进行研究，并与30名健康女性对照者进行比较。采用同位素方法使用C-14苄胺测量血小板MAO活性。使用特定评分量表测量冲动性人格特征，并使用克隆宁格的气质性格问卷（TCI）研究气质。
厌食症患者的血小板MAO活性（4.3 + 2.7纳摩尔/小时/10⁸血小板）显著低于对照组（6.7 + 2.8）（P < 0.01）。血小板MAO与冲动性量表得分呈负相关，与克隆宁格TCI的“坚持性”维度呈正相关。
神经性厌食症患者组的血小板MAO活性降低，可能涉及冲动控制调节的某些功能障碍。
