Abheiden Carolien Nienke Heleen, van Reuler Alexandra Vera Ruth, Fuijkschot Wessel Willem, de Vries Johanna Inge Petra, Thijs Abel, de Boer Marjon Alina
Department of Obstetrics and Gynecology, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Department of Internal Medicine, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Pregnancy Hypertens. 2016 Oct;6(4):350-355. doi: 10.1016/j.preghy.2016.08.232. Epub 2016 Aug 6.
Aspirin reduces the risk of recurrent hypertensive disorders of pregnancy (HD) and fetal growth restriction (FGR). This study examined the non-adherence rates of aspirin in women with high-risk pregnancies.
All consecutive women between 24 and 36weeks gestation with an indication for aspirin use during pregnancy were invited for this study. A survey was used which included two validated questionnaires, the simplified medication adherence questionnaire (SMAQ) and the Beliefs and Behaviour Questionnaire (BBQ).
To determine the non-adherence rates of aspirin, and to identify the beliefs and behavior concerning aspirin.
Indications for aspirin use during pregnancy were previous HD, FGR, intrauterine fetal death or current maternal disease. Non-adherence rates according to the SMAQ and BBQ were 46.3% and 21.4% respectively. No differences in demographic background or obstetrical characteristics between adherent and non-adherent women could be demonstrated.
Adherence for aspirin in this high-risk population cannot be taken for granted. The non-adherence rates in pregnant women are comparable with the non-adherence rates for aspirin in the non-pregnant population.
阿司匹林可降低妊娠期间高血压疾病复发（HD）和胎儿生长受限（FGR）的风险。本研究调查了高危妊娠女性中阿司匹林的不依从率。
邀请所有妊娠24至36周、孕期有使用阿司匹林指征的连续入组女性参与本研究。采用了一项调查，其中包括两份经过验证的问卷，即简化药物依从性问卷（SMAQ）和信念与行为问卷（BBQ）。
确定阿司匹林的不依从率，并识别与阿司匹林相关的信念和行为。
孕期使用阿司匹林的指征为既往HD、FGR、胎儿宫内死亡或当前的母体疾病。根据SMAQ和BBQ得出的不依从率分别为46.3%和21.4%。依从和不依从女性在人口统计学背景或产科特征方面未显示出差异。
在这一高危人群中，不能想当然地认为阿司匹林的依从性良好。孕妇的不依从率与非孕妇人群中阿司匹林的不依从率相当。
