Oklinski Michal K, Skowronski Mariusz T, Skowronska Agnieszka, Rützler Michael, Nørgaard Kirsten, Nieland John D, Kwon Tae-Hwan, Nielsen Søren
Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.
Department of Animal Physiology, University of Warmia and Mazury in Olsztyn, 10-752 Olsztyn, Poland.
Int J Mol Sci. 2016 Dec 7;17(12):2050. doi: 10.3390/ijms17122050.
Aquaporins (AQPs) are water channel proteins robustly expressed in the central nervous system (CNS). A number of previous studies described the cellular expression sites and investigated their major roles and function in the brain and spinal cord. Among thirteen different mammalian AQPs, AQP1 and AQP4 have been mainly studied in the CNS and evidence has been presented that they play important roles in the pathogenesis of CNS injury, edema and multiple diseases such as multiple sclerosis, neuromyelitis optica spectrum disorders, amyotrophic lateral sclerosis, glioblastoma multiforme, Alzheimer's disease and Parkinson's disease. The objective of this review is to highlight the current knowledge about AQPs in the spinal cord and their proposed roles in pathophysiology and pathogenesis related to spinal cord lesions and injury.
水通道蛋白（AQPs）是在中枢神经系统（CNS）中大量表达的水通道蛋白。先前的一些研究描述了其细胞表达位点，并研究了它们在脑和脊髓中的主要作用及功能。在13种不同的哺乳动物水通道蛋白中，AQP1和AQP4主要在中枢神经系统中得到研究，并且有证据表明它们在中枢神经系统损伤、水肿以及多种疾病（如多发性硬化症、视神经脊髓炎谱系障碍、肌萎缩侧索硬化症、多形性胶质母细胞瘤、阿尔茨海默病和帕金森病）的发病机制中发挥重要作用。本综述的目的是强调目前关于脊髓中水通道蛋白的知识，以及它们在与脊髓病变和损伤相关的病理生理学和发病机制中所提出的作用。
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