5-羟色胺对家兔快速适应性肺牵张感受器活动的影响。

Effects of 5-hydroxytryptamine on rapidly adapting pulmonary stretch receptor activity in the rabbit.

作者信息

Matsumoto S, Shimizu T

机构信息

First Department of Physiology, Fukushima Medical College, Japan.

出版信息

J Auton Nerv Syst. 1989 Jun;27(1):35-8. doi: 10.1016/0165-1838(89)90126-4.

DOI:10.1016/0165-1838(89)90126-4

PMID:2794342

Abstract

In anesthetized rabbits, intravenous administration of 5-hydroxytryptamine (5-HT, 10, 20, 40 and 80 micrograms/kg) led to an increase of rapidly adapting pulmonary stretch receptor activity. The magnitude of the increase was dose-dependent. The excitatory responses to any doses of 5-HT were not inhibited by prior treatment with isoprenaline (100-150 micrograms). The results indicate that the stimulation of rapidly adapting pulmonary stretch receptors by 5-HT is not caused by contraction of the airway smooth muscle.

摘要

在麻醉兔中，静脉注射5-羟色胺（5-HT，10、20、40和80微克/千克）导致快速适应型肺牵张感受器活动增加。增加的幅度呈剂量依赖性。预先用异丙肾上腺素（100 - 150微克）处理并不能抑制对任何剂量5-HT的兴奋反应。结果表明，5-HT对快速适应型肺牵张感受器的刺激不是由气道平滑肌收缩引起的。