Scharbach H
Acta Psychiatr Belg. 1978 Mar-Apr;78(2):358-73.
A new group of substances blocking central beta receptors, ie beta blocking agents among which oxprenol and pindolol, have been used in psychiatry, mainly in anxious or depressive-anxious patients. The anxiolytic effect, particularly on somatic anxiety, is interesting, and is present in double blind studies with benzodiazepines, where it is superior to these classical agents. The author has observed this therapeutic activity in series of one hundred patients and also a dynamising effect in some of these patients. Without having observed by himself and possibly because of the low doses experimented, the author states that these drugs have an antipsychotic activity.
一组新的阻断中枢β受体的物质,即β阻滞剂,其中氧烯洛尔和吲哚洛尔,已被用于精神病学领域,主要用于焦虑或抑郁焦虑患者。其抗焦虑作用,特别是对躯体焦虑的作用很有意思,在与苯二氮䓬类药物的双盲研究中也有体现,在这些研究中,其效果优于这些传统药物。作者在100例患者系列中观察到了这种治疗活性,并且在其中一些患者中还观察到了振奋作用。作者本人并未观察到,可能是由于所试验的剂量较低,作者指出这些药物具有抗精神病活性。