Takeo Y, Tominaga K, Tsuji H, Yoh K, Nakano K
Department of Orthopaedic Surgery, Hyogo Prefectural Nishinomiya Hospital, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1989 May;63(5):507-13.
The recovery of renal osteodystrophy can be achieved by renal transplantation but secondary bone changes appear after transplantation due to immunological reaction and immunosuppressive drugs. Very few cases of spontaneous fracture and osteoporosis have been documented among patients after renal transplantation. This was investigated from roentgenologic, histologic, biochemical, and immunological viewpoints in 180 transplant patients treated at Hyogo Prefectural Nishinomiya Hospital. The following conclusions were obtained. (1) Among 180 patients, spontaneous fractures occurred in 22%. (2) Pathogenesis of the fracture of transplant patient was found to be related to steroid induced osteoporosis and not to renal osteodystrophy. (3) There was no relation between spontaneous fracture and OKT4/OKT8 ratio.
肾性骨营养不良可通过肾移植得以恢复，但移植后由于免疫反应和免疫抑制药物会出现继发性骨改变。肾移植患者中记录到的自发性骨折和骨质疏松病例极少。我们从X线、组织学、生化和免疫学角度，对兵库县西宫市立医院治疗的180例移植患者进行了调查。得出以下结论：（1）180例患者中，22%发生了自发性骨折。（2）发现移植患者骨折的发病机制与类固醇诱导的骨质疏松有关，而非与肾性骨营养不良有关。（3）自发性骨折与OKT4/OKT8比值之间没有关系。
