Yen C K, Koblik P, Breznock B, Komtebedde J, Pollycove M, Hornof W J, Fisher P
Department of Nuclear Medicine, Pacific Presbyterian Medical Center, San Francisco, California.
J Nucl Med. 1989 Oct;30(10):1702-7.
Following transrectal administration, 123I iodoamphetamine (IMP) has been shown in both animal and patient studies to be capable of detecting the presence of portasystemic shunting (PSS). However, the ability of this method to actually quantitate PSS in the presence of cirrhosis and propranolol has not been demonstrated. We studied nine dogs with hitologically proven cirrhosis induced by chronic bile duct ligation. After intravenous injection of propranolol, PSS were measured with both the IMP method and the standard of portal vein infusion of 99mTc macroaggregated albumin (MAA) given through a mesenteric vein catheter. Based on linear regression, a close relationship was seen, given by the equation: MAA = IMP 0.9 + 0.035, with correlation coefficient of 0.99. Thus, in dogs with cirrhosis secondary to chronic bile duct ligation and after propranolol administration, PSS can be quantitated with the transrectal IMP method.
经直肠给药后，动物研究和患者研究均表明，123I 碘安非他明（IMP）能够检测出门体分流（PSS）的存在。然而，该方法在肝硬化和普萘洛尔存在的情况下实际定量 PSS 的能力尚未得到证实。我们研究了 9 只经组织学证实由慢性胆管结扎诱导肝硬化的犬。静脉注射普萘洛尔后，采用 IMP 法和通过肠系膜静脉导管经门静脉输注 99mTc 标记的大颗粒白蛋白（MAA）的标准方法测量 PSS。基于线性回归，发现两者存在密切关系，方程为：MAA = IMP×0.9 + 0.035，相关系数为 0.99。因此，在慢性胆管结扎继发肝硬化且给予普萘洛尔后的犬中，可采用经直肠 IMP 法对 PSS 进行定量。
