Sarwal S, Sanyal S N, Khera S
Department of Zoology, Panjab University, Chandigarh, India.
J Parasitol. 1989 Oct;75(5):808-10.
The effects of 2 benzimidazole drugs, fenbendazole and thiabendazole, on the enzymes of lipid metabolism of an intestinal nematode parasite, Trichuris globulosa, have been studied. In vitro addition of these drugs inhibited the activity of these enzymes in both male and female worms. Inhibition is competitive in the case of the lipogenic enzymes, malate dehydrogenase and glucose-6-phosphate dehydrogenase; whereas, it is noncompetitive in the case of the lipolytic enzyme, triacylglycerol lipase. Cholesterol biosynthesis is, however, not affected.
研究了两种苯并咪唑类药物芬苯达唑和噻苯达唑对肠道线虫寄生虫球形鞭虫脂质代谢酶的影响。在体外添加这些药物会抑制雌雄虫体内这些酶的活性。对于生脂酶苹果酸脱氢酶和葡萄糖-6-磷酸脱氢酶，抑制作用是竞争性的；而对于脂解酶三酰甘油脂肪酶，抑制作用是非竞争性的。然而，胆固醇生物合成不受影响。
