Ticho B H, Tso M O, Kishi S
Department of Ophthalmology, Lions of Illinois Eye Research Institute, University of Illinois College of Medicine, Chicago.
J Pediatr Ophthalmol Strabismus. 1989 Sep-Oct;26(5):244-50. doi: 10.3928/0191-3913-19890901-10.
We studied by light and electron microscopy the diffuse iris nevus of an eye in a 16-year-old patient with oculodermal melanocytosis and choroidal malignant melanoma. The nevus cells in the anterior border layer of the iris appeared to be poorly differentiated, showing moderate infolding of the nuclear membrane with heterochromatin clumping, watery cytoplasm, abundant mitochondria, fine filaments, rough endoplasmic reticulum, and numerous pinocytotic vesicles. Small scattered immature melanosomes and occasional giant melanosomes were observed in these cells. Deep in the iris stroma, however, nevus cells were found singly or in small groups, and were associated with an increasing number of melanized melanosomes and cytoplasmic filaments and reduced numbers of other cytoplasmic organelles, such as mitochondria and free ribosomes. Differentiation of the iris nevus cells appeared to progress from the anterior border layer toward the iris stroma. This observation suggests that intrastromal nevi may be more benign than nevi with surface plaque. The ultrastructural characteristics of the diffuse nevi of oculodermal melanocytosis were compared with those of other iris nevi.
我们通过光学显微镜和电子显微镜研究了一名患有眼皮肤黑素细胞增多症和脉络膜恶性黑色素瘤的16岁患者眼部的弥漫性虹膜痣。虹膜前缘层的痣细胞似乎分化不良，核膜有中度内褶，异染色质聚集，细胞质水样，线粒体丰富，有细丝、粗面内质网和大量吞饮小泡。在这些细胞中观察到散在的小而不成熟的黑素小体和偶尔的巨大黑素小体。然而，在虹膜基质深处，痣细胞单个或成小群存在，并伴有越来越多的黑素化黑素小体和细胞质细丝，而线粒体和游离核糖体等其他细胞质细胞器的数量减少。虹膜痣细胞的分化似乎从前缘层向虹膜基质发展。这一观察结果表明，基质内痣可能比有表面斑块的痣更良性。将眼皮肤黑素细胞增多症的弥漫性痣的超微结构特征与其他虹膜痣的特征进行了比较。
