Vaughan J A, Jerse A E, Azad A F
J Med Entomol. 1989 Sep;26(5):449-53. doi: 10.1093/jmedent/26.5.449.
The host response to bites of the oriental rat flea, Xenopyslla cheopis Rothschild, was investigated by examining rat blood leucocyte kinetics, histopathology, and the effect that the host response had upon subsequent flea feeding and longevity. Test rats were subjected to controlled exposures of fleas, and leucocyte data from test rats were compared to those of unexposed controls. Of the five leucocyte types examined, only the basophil appeared to play a role in the host blood response to flea bites. Significant increases in blood basophil levels occurred 2-3 d after exposure but subsided to control levels within a week. However, flea feeding did not produce histopathology at the flea feeding sites nor did the basophilic blood response of rats affect subsequent feeding or longevity of the fleas.
通过检测大鼠血液白细胞动力学、组织病理学以及宿主反应对后续跳蚤进食和寿命的影响，研究了宿主对东方鼠蚤（Xenopyslla cheopis Rothschild）叮咬的反应。将试验大鼠置于可控的跳蚤暴露环境中，并将试验大鼠的白细胞数据与未暴露的对照大鼠的数据进行比较。在所检测的五种白细胞类型中，只有嗜碱性粒细胞似乎在宿主对跳蚤叮咬的血液反应中发挥作用。暴露后2 - 3天，血液嗜碱性粒细胞水平显著升高，但在一周内降至对照水平。然而，跳蚤进食并未在跳蚤进食部位产生组织病理学变化，大鼠的嗜碱性血液反应也未影响跳蚤随后的进食或寿命。
