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12种抗真菌药物对来自伊朗、土耳其和中国头癣黄癣患者的55株许兰毛癣菌分离株的体外抗真菌药敏谱

In Vitro Antifungal Susceptibility Profiles of 12 Antifungal Drugs against 55 Trichophyton schoenleinii Isolates from Tinea Capitis Favosa Patients in Iran, Turkey, and China.

作者信息

Deng Shuwen, Ansari Saham, Ilkit Macit, Rafati Haleh, Hedayati Mohammad T, Taghizadeh-Armaki Mojtaba, Nasrollahi-Omran Ayatollah, Tolooe Ali, Zhan Ping, Liao Wanqing, van der Lee Henrich A, Verweij Paul E, Seyedmousavi Seyedmojtaba

机构信息

Shanghai Key Laboratory of Molecular Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

First Hospital of Xinjiang Medical University, Xinjiang, China.

出版信息

Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.01753-16. Print 2017 Feb.

Abstract

Trichophyton schoenleinii is an anthropophilic dermatophyte mainly causing tinea favosa of the scalp in certain regions of the world, especially Africa and Asia. We investigated the in vitro susceptibilities of 55 T. schoenleinii isolates collected over the last 30 years from Iran, Turkey, and China to 12 antifungals using the CLSI broth microdilution method. Our results revealed that terbinafine and ketoconazole were the most potent antifungal agents among those tested, independently of the geographic regions where strains were isolated.

摘要

许兰毛癣菌是一种亲人性皮肤癣菌,在世界某些地区,尤其是非洲和亚洲,主要引起头皮黄癣。我们采用美国临床和实验室标准协会(CLSI)肉汤微量稀释法,调查了过去30年从伊朗、土耳其和中国收集的55株许兰毛癣菌分离株对12种抗真菌药物的体外敏感性。我们的结果显示,在所测试的抗真菌药物中,特比萘芬和酮康唑是最有效的,与分离菌株的地理区域无关。

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