Huzmeli Can, Eliacik Eylem, Saglam Mustafa, Doner Baris, Candan Ferhan
Necip Fazıl City Hospital, Department of Nephrology, Kahramanmaras, Turkey.
Necip Fazıl City Hospital, Department of Hematology, Kahramanmaras, Turkey.
Case Rep Med. 2016;2016:9620520. doi: 10.1155/2016/9620520. Epub 2016 Nov 10.
The tumor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur in consequence of the release of intracellular contents following lysis of tumor cells. TLS occurs spontaneously or after chemotherapy. Spontaneous TLS is uncommon occurrence in multiple myeloma (MM). We define a case of a 70-year-old woman patient who was found to have MM with spontaneous TLS, following a compression fracture of the T-12 vertebrae. While serum uric acid and phosphorous levels were high, low calcium levels were identified. There were also acute kidney injury and metabolic acidosis. Upon the diagnosis of TLS, she was treated with hydration, allopurinol, sodium bicarbonate, and calcium gluconate. The improvement of her laboratory data was observed. We submitted this case in order to draw attention to the presentation of MM with spontaneous TLS.
肿瘤溶解综合征（TLS）是一组代谢异常，其发生是肿瘤细胞溶解后细胞内成分释放的结果。TLS可自发出现或在化疗后出现。自发TLS在多发性骨髓瘤（MM）中并不常见。我们报道一例70岁女性患者，在第12胸椎压缩性骨折后被发现患有MM并伴有自发TLS。虽然血清尿酸和磷水平升高，但血钙水平降低。同时还存在急性肾损伤和代谢性酸中毒。诊断为TLS后，她接受了补液、别嘌醇、碳酸氢钠和葡萄糖酸钙治疗。观察到其实验室数据有所改善。我们提交此病例是为了引起对MM伴自发TLS表现的关注。
