Hematology/Oncology, University of Rochester, Rochester, New York, USA
Internal Medicine, Unity Hospital, Rochester, New York, USA.
BMJ Case Rep. 2021 Feb 5;14(2):e234122. doi: 10.1136/bcr-2019-234122.
Tumour lysis syndrome (TLS) is a constellation of metabolic derangements caused by lysis of tumour cells. It is an oncological emergency that is considered a rare occurrence in multiple myeloma (MM) and usually occurs after patients have been treated with chemotherapy. We describe a very rare case of TLS occurring before the official diagnosis or treatment of MM. We report infrequent karyotype abnormalities, including loss of 17p13.1 ( mutation), t(4;14) () and monosomy 13, that have not been explicitly described in association with spontaneous tumour lysis syndrome (STLS) in MM. This case adds to the sparse literature available on STLS in MM, which is a life-threatening situation requiring urgent medical intervention.
肿瘤细胞溶解综合征 (TLS) 是由肿瘤细胞溶解引起的代谢紊乱的综合征。它是一种肿瘤急症，在多发性骨髓瘤 (MM) 中被认为是罕见的，通常发生在患者接受化疗后。我们描述了一例非常罕见的 TLS 在 MM 的正式诊断或治疗之前发生的病例。我们报告了不常见的核型异常，包括 17p13.1 缺失 ( 突变)、t(4;14)()和 13 单体，这些异常与 MM 中的自发性肿瘤细胞溶解综合征 (STLS) 并无明确关联。该病例增加了 MM 中 STLS 的文献记载，这种情况危及生命，需要紧急医疗干预。
