Nemolato Sonia, Ravarino Alberto, Fanni Daniela, Coni Pierpaolo, Di Felice Eliana, Senes Giancarlo, Faa Gavino
Department of Cytomorphlogy, Division of Pathology, University of Cagliari, Cagliari, Italy; Corrisponding Author: Dipartimento di Citomorfologia, Divisione di Anatomia Patologica, Universita di Cagliari, Via Ospedale 46, 09124 Cagliari, Italy. Email:
Department of Cytomorphlogy, Division of Pathology, University of Cagliari, Cagliari, Italy.
Gastroenterology Res. 2009 Oct;2(5):277-281. doi: 10.4021/gr2009.10.1313. Epub 2009 Sep 20.
This study was aimed at evaluating the correlation between Hepatocyte paraffin 1 (Hep par 1) and colorectal cancer.
To this end, 50 intestinal biopsies were analyzed including 10 colorectal polyps with low grade dysplasia, 10 with high grade dysplasia, 10 colorectal adenocarcinomas, 10 specimens of normal ileum and 10 of normal colon mucosa. Tissue sections were immunostained for Hep par 1 utilizing a commercial antibody. Normal colonic mucosa did not express Hep par 1.
Immunoreactivity for Hep par 1 was detected in 20% of polyps with low grade dysplasia, 50% of polyps with high grade dysplasia and 60% of colorectal carcinomas. Hep par 1 was frequently detected in the deepest areas of adenocarcinomas mainly in infiltrating tumour cells.
Our data show that Hep par 1 immunoreactivity in human colon carcinogenesis is correlated with progression from low grade to high grade dysplasia and adenocarcinoma. In clinical practice, our data show that caution should be taken in utilizing Hep par 1 as the sole tool in differentiating hepatocellular carcinoma from a liver metastasis of colon adenocarcinoma. Our data encourage further investigations into the potential role played by Hep par 1 in gastrointestinal carcinogenesis.
本研究旨在评估肝细胞石蜡1（Hep par 1）与结直肠癌之间的相关性。
为此，分析了50份肠道活检样本，包括10份低级别发育异常的结肠息肉、10份高级别发育异常的结肠息肉、10份结肠腺癌、10份正常回肠标本和10份正常结肠黏膜标本。利用商业抗体对组织切片进行Hep par 1免疫染色。正常结肠黏膜不表达Hep par 1。
在20%的低级别发育异常息肉、50%的高级别发育异常息肉和60%的结肠腺癌中检测到Hep par 1免疫反应性。Hep par 1在腺癌的最深层区域经常被检测到，主要存在于浸润性肿瘤细胞中。
我们的数据表明，人类结肠癌发生过程中Hep par 1免疫反应性与从低级别到高级别发育异常以及腺癌的进展相关。在临床实践中，我们的数据表明，在将Hep par 1作为区分肝细胞癌与结肠腺癌肝转移的唯一工具时应谨慎。我们的数据鼓励进一步研究Hep par 1在胃肠道癌发生中所起的潜在作用。
