新型缺氧正电子发射断层显像示踪剂[F]HX4在非小细胞肺癌患者中的药代动力学建模
Pharmacokinetic modeling of a novel hypoxia PET tracer [F]HX4 in patients with non-small cell lung cancer.
作者信息
Verwer E E, Zegers C M L, van Elmpt W, Wierts R, Windhorst A D, Mottaghy F M, Lambin P, Boellaard R
机构信息
Department of Radiology & Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Department of Nuclear Medicine & Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
出版信息
EJNMMI Phys. 2016 Dec;3(1):30. doi: 10.1186/s40658-016-0167-y. Epub 2016 Dec 12.
BACKGROUND
[F]HX4 is a promising new PET tracer developed to identify hypoxic areas in tumor tissue. This study analyzes [F]HX4 kinetics and assesses the performance of simplified methods for quantification of [F]HX4 uptake. To this end, eight patients with non-small cell lung cancer received dynamic PET scans at three different time points (0, 120, and 240 min) after injection of 426 ± 72 MBq [F]HX4, each lasting 30 min. Several compartment models were fitted to time activity curves (TAC) derived from various areas within tumor tissue using image-derived input functions.
RESULTS
Best fits were obtained using the reversible two-tissue compartment model with blood volume parameter (2T4k+V). Simplified measures correlated well with V estimates (tumor-to-blood ratio (TBr) R = 0.96, tumor-to-muscle ratio R = 0.94, standardized uptake value R = 0.89).
CONCLUSIONS
[F]HX4 shows reversible kinetics in tumor tissue: 2T4k+V. TBr based on static imaging at 2 or 4 h can be used for quantification of [F]HX4 uptake.
背景
[F]HX4是一种有前景的新型正电子发射断层显像（PET）示踪剂，用于识别肿瘤组织中的缺氧区域。本研究分析了[F]HX4的动力学，并评估了[F]HX4摄取定量简化方法的性能。为此，8例非小细胞肺癌患者在注射426±72MBq[F]HX4后的三个不同时间点（0、120和240分钟）接受了动态PET扫描，每次扫描持续30分钟。使用图像衍生输入函数，将几个房室模型拟合到从肿瘤组织内各个区域得出的时间-活度曲线（TAC）。
结果
使用具有血容量参数的可逆双组织房室模型（2T4k+V）获得了最佳拟合。简化测量值与V估计值相关性良好（肿瘤与血液比值（TBr）R = 0.96，肿瘤与肌肉比值R = 0.94，标准化摄取值R = 0.89）。
结论
[F]HX4在肿瘤组织中显示出可逆动力学：2T4k+V。基于2或4小时静态成像的TBr可用于[F]HX4摄取的定量分析。
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