Andrade Bellido R J, Escolar Castellón J L, Aguado Guerrero F, Valdivielso Felices P, González Santos P
Med Clin (Barc). 1989 Jul 1;93(5):169-72.
To assess the abnormalities induced by alcohol on plasma lipids and lipoproteins and their possibly involved mechanisms three basis of the daily intake: social drinkers (less than or equal to 20 g/day; n = 10), moderate drinkers (greater than 20 to less than 70 g/day; n = 11), and severe drinkers (greater than or equal to 70 g/day; n = 15). Eleven nondrinkers were evaluated as control group. Very low density lipoproteins (VLDL), low density lipoproteins (LDL), high density lipoproteins (HDL)-2 and HDL-3 were isolated by preparative sequential isopicnic centrifugation, and their apolipoprotein and lipidic composition were measured. In the group of severe drinkers, a marked tendency of HDL-3 cholesterol to be higher than in the remaining groups was found. There was no correlation between this parameter and hepatic enzymes. The HDL-2 cholesterol of severe drinkers was significantly increased (p less than 0.005). The parallel enrichment in apolipoproteins C of the HDL-2 particle in all groups of alcohol users suggests a transfer phenomenon from VLDL. The apoA/C ratio of HDL-2 might be useful as a marker of alcohol intake.
为评估酒精对血浆脂质和脂蛋白的影响及其可能的作用机制，根据每日摄入量将研究对象分为三组：社交饮酒者（每日摄入量≤20克；n = 10）、中度饮酒者（每日摄入量>20至<70克；n = 11）和重度饮酒者（每日摄入量≥70克；n = 15）。选取11名不饮酒者作为对照组。通过制备性连续等密度离心法分离极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）-2和HDL-3，并测定其载脂蛋白和脂质成分。在重度饮酒组中，发现HDL-3胆固醇有明显高于其他组的趋势。该参数与肝酶之间无相关性。重度饮酒者的HDL-2胆固醇显著升高（p<0.005）。所有饮酒组中HDL-2颗粒载脂蛋白C的平行富集表明存在从VLDL的转移现象。HDL-2的载脂蛋白A/载脂蛋白C比值可能作为酒精摄入量的标志物。
