Rosseneu M, Stellamans G, Vercaemst R, Belpaire F
Artery. 1982;10(3):193-201.
The plasma lipid and apoprotein concentrations were monitored in a group of 12 patients with chronic alcohol abuse entering an abstinence program for 3 weeks. 6 of them had a normal liver function as expressed by the levels of liver enzymes gamma GT, GOT, GPT, while 6 had elevated plasma liver enzyme concentrations. None had evidence of either cirrhosis or alcohol hepatitis. Patients with abnormal liver enzymes had elevated HDL-cholesterol, apo AI and apo AII concentrations in plasma, with normal total cholesterol and apo 8 concentrations. In the group of patients with normal liver enzyme concentrations, the apoproteins and lipids did not significantly differ from the control group. In the course of the abstinence treatment a parallel decrease of apoproteins, HDL-cholesterol and liver enzyme concentrations was observed. The values normalized after 10-15 days. These data indicate that the effect of alcohol on the plasma apoprotein and lipids occurs mostly in the HDL fraction, that it correlates with the state of hepatic function and that it can be reversed by an abstinence treatment.
对一组12名慢性酒精滥用患者进行了为期3周的戒酒计划，并监测了他们的血浆脂质和载脂蛋白浓度。其中6名患者的肝功能正常，以肝酶γ-GT、GOT、GPT水平表示，而另外6名患者的血浆肝酶浓度升高。没有人有肝硬化或酒精性肝炎的证据。肝酶异常的患者血浆中HDL-胆固醇、载脂蛋白AI和载脂蛋白AII浓度升高，总胆固醇和载脂蛋白B浓度正常。在肝酶浓度正常的患者组中，载脂蛋白和脂质与对照组无显著差异。在戒酒治疗过程中，观察到载脂蛋白、HDL-胆固醇和肝酶浓度平行下降。10-15天后数值恢复正常。这些数据表明，酒精对血浆载脂蛋白和脂质的影响主要发生在HDL部分，它与肝功能状态相关，并且可以通过戒酒治疗逆转。
