Liu Jiayong, Gao Yanhui, Liu Hongxu, Sun Jing, Liu Yang, Wu Junhua, Li Dandan, Sun Dianjun
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, China and Russia Medical Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.
Int J Hyg Environ Health. 2017 Apr;220(2 Pt B):424-430. doi: 10.1016/j.ijheh.2016.12.004. Epub 2016 Dec 8.
In this study, the relationships between high water arsenic exposure and cognitive impairment were investigated. A total of 483 residents aged 40 or older were randomly recruited and were divided into four groups according to the concentrations of arsenic in their water. Consumption levels (̄x¯±s) of drinking water arsenic for normal, mild, moderate, and high exposure groups were 4±2μg/L, 25±11μg/L, 73±15μg/L, and 183±88μg/L, respectively. The average scores (̄x¯±s) of the Chinese version Mini-Mental State Examination (MMSE) for females in each group were 21.49±3.14, 19.04±5.87, 16.18±8.14, and 15.82±7.78, and the average scores (̄x¯±s) for males were 24.50±3.97, 23.16±4.45, 21.00±6.57, and 18.92±7.99, respectively. Significant differences among the average scores of MMSE for males or females in the four groups were found (p<0.05). The prevalence of cognitive impairment for females in each group was 10.86%, 29.63%, 53.48%, and 55.29%, and the prevalence of cognitive impairment for males was 10.71%, 12.00%, 35.71%, and 50.89%, respectively. Significant differences between all groups were observed (p<0.05). In the multivariable regress model, high water was closely associated with the MMSE score (Standardized Coefficient=-0.021) and cognitive impairment (arsenic ˃100 μg/L PR=4.01). The findings of our research suggested a significant positive relationship between arsenic exposure from drinking water and cognitive impairment.
在本研究中，调查了高水砷暴露与认知障碍之间的关系。共随机招募了483名40岁及以上的居民，并根据其饮用水中砷的浓度将他们分为四组。正常、轻度、中度和高暴露组饮用水砷的消费水平（̄x¯±s）分别为4±2μg/L、25±11μg/L、73±15μg/L和183±88μg/L。每组女性中文版简易精神状态检查表（MMSE）的平均得分（̄x¯±s）分别为21.49±3.14、19.04±5.87、16.18±8.14和15.82±7.78，男性的平均得分（̄x¯±s）分别为24.50±3.97、23.16±4.45、21.00±6.57和18.92±7.99。发现四组男性或女性MMSE平均得分之间存在显著差异（p<0.05）。每组女性认知障碍的患病率分别为10.86%、29.63%、53.48%和�5.29%，男性认知障碍的患病率分别为10.71%、12.00%、35.71%和50.89%。观察到所有组之间存在显著差异（p<0.05）。在多变量回归模型中，高水与MMSE得分密切相关（标准化系数=-0.021）和认知障碍（砷>100μg/L，PR=4.01）。我们的研究结果表明，饮用水中的砷暴露与认知障碍之间存在显著的正相关关系。
