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成年大鼠三叉神经节中谷氨酸能神经传递相关基因和蛋白质的感觉输入依赖性变化

Sensory Input-Dependent Changes in Glutamatergic Neurotransmission- Related Genes and Proteins in the Adult Rat Trigeminal Ganglion.

作者信息

Fernández-Montoya Julia, Buendia Izaskun, Martin Yasmina B, Egea Javier, Negredo Pilar, Avendaño Carlos

机构信息

Departamento de Anatomía, Histología y Neurociencia, Universidad Autónoma de Madrid Madrid, Spain.

Instituto de Investigación Sanitaria, Hospital Universitario de La PrincesaMadrid, Spain; Departamento de Farmacología y Terapéutica, Instituto Teófilo Hernando, Universidad Autónoma de MadridMadrid, Spain.

出版信息

Front Mol Neurosci. 2016 Nov 28;9:132. doi: 10.3389/fnmol.2016.00132. eCollection 2016.

DOI:10.3389/fnmol.2016.00132
PMID:27965535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5124698/
Abstract

Experience-dependent plasticity induces lasting changes in the structure of synapses, dendrites, and axons at both molecular and anatomical levels. Whilst relatively well studied in the cortex, little is known about the molecular changes underlying experience-dependent plasticity at peripheral levels of the sensory pathways. Given the importance of glutamatergic neurotransmission in the somatosensory system and its involvement in plasticity, in the present study, we investigated gene and protein expression of glutamate receptor subunits and associated molecules in the trigeminal ganglion (TG) of young adult rats. Microarray analysis of naïve rat TG revealed significant differences in the expression of genes, coding for various glutamate receptor subunits and proteins involved in clustering and stabilization of AMPA receptors, between left and right ganglion. Long-term exposure to sensory-enriched environment increased this left-right asymmetry in gene expression. Conversely, unilateral whisker trimming on the right side almost eliminated the mentioned asymmetries. The above manipulations also induced side-specific changes in the protein levels of glutamate receptor subunits. Our results show that sustained changes in sensory input induce modifications in glutamatergic transmission-related gene expression in the TG, thus supporting a role for this early sensory-processing node in experience-dependent plasticity.

摘要

经验依赖性可塑性在分子和解剖学水平上都会引起突触、树突和轴突结构的持久变化。虽然在皮质中对此研究得相对充分，但对于感觉通路外周水平上经验依赖性可塑性背后的分子变化却知之甚少。鉴于谷氨酸能神经传递在体感系统中的重要性及其与可塑性的关联，在本研究中，我们调查了成年幼鼠三叉神经节（TG）中谷氨酸受体亚基及相关分子的基因和蛋白表达情况。对未接触过特定环境的大鼠TG进行微阵列分析发现，左右神经节之间，编码各种谷氨酸受体亚基以及参与AMPA受体聚集和稳定的蛋白质的基因表达存在显著差异。长期暴露于丰富感觉环境会增加基因表达中的这种左右不对称性。相反，右侧单侧触须修剪几乎消除了上述不对称性。上述操作还诱导了谷氨酸受体亚基蛋白水平的侧特异性变化。我们的结果表明，感觉输入的持续变化会诱导TG中谷氨酸能传递相关基因表达的改变，从而支持这个早期感觉处理节点在经验依赖性可塑性中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/74edca0d27d5/fnmol-09-00132-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/d8ab05d4063e/fnmol-09-00132-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/96104d750aaf/fnmol-09-00132-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/10c3261c780c/fnmol-09-00132-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/74edca0d27d5/fnmol-09-00132-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/d8ab05d4063e/fnmol-09-00132-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/96104d750aaf/fnmol-09-00132-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/10c3261c780c/fnmol-09-00132-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f3/5124698/74edca0d27d5/fnmol-09-00132-g004.jpg

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