Lukacs-Kornek Veronika
Department of Medicine II, Saarland University Medical Center , Homburg , Germany.
Front Immunol. 2016 Nov 29;7:548. doi: 10.3389/fimmu.2016.00548. eCollection 2016.
Lymphatics and lymphatic endothelial cells (LECs) possess multiple immunological functions besides affecting immune cell migration, such as inhibiting T cell proliferation and antigen presentation by dendritic cells. Moreover, they control the trans-endothelial transport of multiple molecules and antigens. Emerging evidence suggest their active involvements in immunregulation, tumor, and metastases formation. In the liver, increased lymphangiogenesis, specifically at the portal area has been associated with multiple liver diseases in particular primary biliary cirrhosis, idiopathic portal hypertension, and liver malignancies. Nevertheless, the exact role and contribution of LECs to liver diseases are poorly understood. The review summarizes the current understanding of LECs in liver diseases.
淋巴管和淋巴管内皮细胞（LECs）除了影响免疫细胞迁移外，还具有多种免疫功能，如抑制T细胞增殖和树突状细胞的抗原呈递。此外，它们还控制多种分子和抗原的跨内皮运输。新出现的证据表明它们积极参与免疫调节、肿瘤和转移形成。在肝脏中，淋巴管生成增加，特别是在门静脉区域，与多种肝脏疾病有关，尤其是原发性胆汁性肝硬化、特发性门静脉高压和肝脏恶性肿瘤。然而，LECs在肝脏疾病中的确切作用和贡献尚不清楚。本综述总结了目前对LECs在肝脏疾病中的认识。
