Grupo de Investigacion Básica y Aplicada en Odontología - IBAPO, Facultad de Odontologia, Universidad Nacional de Colombia, Bogotá, Colombia.
Facultad de Odontología, Unidad de Investigación Básica Oral-UIBO, Universidad El Bosque, Bogotá, Colombia.
Sci Rep. 2024 Nov 29;14(1):29656. doi: 10.1038/s41598-024-77796-7.
The pharmaceutical industry has been primarily focused on developing synthetic drugs to address orofacial pain (OFP)-related conditions. There is limited knowledge regarding the efficacy of the use of herbal extracts in treating OFP. A systematic review and a meta-analysis of 62 randomized controlled trials assessing the analgesic effects of herbal extracts on pain intensity in various orofacial conditions was conducted. The intervention comprised the use of herbal extracts compared with a placebo and/or standard treatment. The primary outcome was pain intensity assessed before and after the intervention. The pain scores were compared with the baseline scores in each treatment. When compared with standard therapy, the pooled results of the patients who received herbal extracts revealed lower pain intensity in periodontal pain (MD = -0.92[-6.69, 4.85]), oral surgery pain (MD = 18.80[8.80, 28.79]), oral neuropathic pain (MD = 20.34[6.16, 34.52]), endodontic pain (MD = -8.04[-11.72, -4.37]), oral mucosal pain (MD = 8.74[2.76, 14.73]), and temporomandibular pain (MD = 30.94[6.04, 55.83]). The findings indicated a pain-attenuating effect of herbal extracts such as cannabis, turmeric, capsaicin, licorice, ginger, chamomile, clove, Hypericum perforatum, and Arnica montana. These findings revindicate that herbal extracts may be valuable alternatives to traditional pain medications and promising source for the development of new active ingredients for pharmaceuticals.
制药行业一直主要专注于开发合成药物来治疗口腔颌面部疼痛（OFP）相关疾病。关于草药提取物治疗 OFP 的疗效知之甚少。对 62 项随机对照试验进行了系统评价和荟萃分析，评估了草药提取物在各种口腔颌面部疾病中对疼痛强度的镇痛效果。干预措施包括使用草药提取物与安慰剂和/或标准治疗相比。主要结局是干预前后疼痛强度的评估。将疼痛评分与每种治疗的基线评分进行比较。与标准治疗相比，接受草药提取物治疗的患者的汇总结果显示，牙周疼痛（MD=-0.92[-6.69,4.85]）、口腔手术疼痛（MD=18.80[8.80,28.79]）、口腔神经病理性疼痛（MD=20.34[6.16,34.52]）、牙髓疼痛（MD=-8.04[-11.72,4.37]）、口腔黏膜疼痛（MD=8.74[2.76,14.73]）和颞下颌疼痛（MD=30.94[6.04,55.83]）的疼痛强度降低。研究结果表明，大麻、姜黄、辣椒素、甘草、生姜、甘菊、丁香、贯叶金丝桃和山金车等草药提取物具有减轻疼痛的作用。这些发现表明，草药提取物可能是传统止痛药的有价值替代品，也是开发新药活性成分的有前途的来源。
