Miric Dijana J, Kisic Bojana M, Filipovic-Danic Snezana, Grbic Rade, Dragojevic Ilija, Miric Marko B, Puhalo-Sladoje Dragana
Institute of Biochemistry, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia.
Clinics for Neurology and Psychiatry, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia.
J Diabetes Res. 2016;2016:4370490. doi: 10.1155/2016/4370490. Epub 2016 Nov 14.
This study investigated the relationship between serum xanthine oxidase (XOD) activity and the occurrence of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. Serum XOD activity, ischemia-modified albumin (IMA), uric acid (UA), albumin, glycated hemoglobin (HbA1c), advanced glycation end products (AGE), total free thiols, atherogenic index of plasma (AIP), and body mass index (BMI) were measured in 80 T2DM patients (29 with and 51 without DPN), and 30 nondiabetic control subjects. Duration of diabetes, hypertension, medication, and microalbuminuria was recorded. Serum XOD activities in controls, non-DPN, and DPN were 5.7 ± 2.4 U/L, 20.3 ± 8.6 U/L, and 27.5 ± 10.6 U/L ( < 0.01), respectively. XOD activity was directly correlated to IMA, UA, BMI, HbA1c, and AGE, while inversely correlated to serum total free thiols. A multivariable logistic regression model, which included duration of diabetes, hypertension, AIP, HbA1c, UA, and XOD activity, revealed HbA1c [OR = 1.03 (1.00-1.05); = 0.034] and XOD activity [OR = 1.07 (1.00-1.14); = 0.036] as independent predictors of DPN. Serum XOD activity was well correlated to several other risk factors. These results indicate the role of XOD in the development of DPN among T2DM patients.
本研究调查了2型糖尿病（T2DM）患者血清黄嘌呤氧化酶（XOD）活性与糖尿病周围神经病变（DPN）发生之间的关系。对80例T2DM患者（29例有DPN，51例无DPN）及30例非糖尿病对照者测定了血清XOD活性、缺血修饰白蛋白（IMA）、尿酸（UA）、白蛋白、糖化血红蛋白（HbA1c）、晚期糖基化终产物（AGE）、总游离巯基、血浆致动脉粥样硬化指数（AIP）和体重指数（BMI）。记录糖尿病病程、高血压、用药情况及微量白蛋白尿。对照组、非DPN组和DPN组的血清XOD活性分别为5.7±2.4 U/L、20.3±8.6 U/L和27.5±10.6 U/L（<0.01）。XOD活性与IMA、UA、BMI、HbA1c和AGE呈正相关，而与血清总游离巯基呈负相关。一个多变量逻辑回归模型，包括糖尿病病程、高血压、AIP、HbA1c、UA和XOD活性，显示HbA1c[比值比（OR）=1.03（1.00 - 1.05）；P = 0.034]和XOD活性[OR = 1.07（1.00 - 1.14）；P = 0.036]是DPN的独立预测因素。血清XOD活性与其他几个危险因素密切相关。这些结果表明XOD在T2DM患者DPN发生中的作用。
