Department of Endocrinology, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, Shanxi, China.
Eur Rev Med Pharmacol Sci. 2023 Aug;27(16):7569-7575. doi: 10.26355/eurrev_202308_33408.
This study aimed to investigate the relationship between serum asprosin level and diabetic peripheral neuropathy (DPN) in community patients with type 2 diabetes mellitus (T2DM).
A total of 498 patients with T2DM were recruited from Zhuoma Community Health Service Station and Chengbei West Street Community Health Service Center in Changzhi City of Shanxi Province between November 2019 and July 2021. Their height, weight, and body mass index (BMI), as well as fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), triglyceride (TG), and serum asprosin levels, were analyzed. Patients were divided into the DPN group (n = 329) and the non-DPN group (n = 169) according to the presence or absence of DPN. The t-test, Mann-Whitney U test, and χ² test were used to compare the indicators between the two groups. Pearson or Spearman correlation analysis was used to evaluate the correlation between serum asprosin and other clinical data. Multivariate logistic regression analysis was used to analyze the influencing factors of DPN.
Compared with the non-DPN group, the DPN group had higher serum asprosin (p < 0.05). The prevalence of DPN gradually increased according to the tertiles of asprosin (56%, 67%, and 75%; p < 0.05). Multivariate logistic regression analysis showed that after adjustment for covariates, patients with asprosin concentrations between 295.4-367.0 pg/ml and concentrations > 367.0 pg/ml had a higher risk of diabetic neuropathy compared than those with asprosin levels < 295.4 pg/ml (p < 0.05).
Serum asprosin was found to be positively correlated with DPN, and it resulted as an influencing factor for DPN in patients with T2DM in the community. With the increase of asprosin, the risk of DPN also increased.
本研究旨在探讨社区 2 型糖尿病（T2DM）患者血清中 asporsin 水平与糖尿病周围神经病变（DPN）的关系。
本研究共纳入 2019 年 11 月至 2021 年 7 月在山西省长治市卓玛社区卫生服务站和城北西街社区卫生服务中心的 498 例 T2DM 患者。分析患者的身高、体重、体重指数（BMI）、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）和血清 asporsin 水平。根据是否存在 DPN 将患者分为 DPN 组（n=329）和非 DPN 组（n=169）。采用 t 检验、Mann-Whitney U 检验和 χ²检验比较两组患者的指标。采用 Pearson 或 Spearman 相关分析评估血清 asporsin 与其他临床资料的相关性。采用多变量 logistic 回归分析分析 DPN 的影响因素。
与非 DPN 组相比，DPN 组患者的血清 asporsin 水平较高（p<0.05）。随着 asporsin 三分位数的升高（56%、67%和 75%；p<0.05），DPN 的患病率逐渐增加。多变量 logistic 回归分析显示，在校正协变量后，asporsin 浓度在 295.4-367.0 pg/ml 之间和浓度>367.0 pg/ml 的患者发生糖尿病神经病变的风险高于 asporsin 水平<295.4 pg/ml 的患者（p<0.05）。
血清 asporsin 与 DPN 呈正相关，是社区 T2DM 患者 DPN 的影响因素。随着 asporsin 的增加，DPN 的风险也随之增加。
