下丘脑后核中的乙酰胆碱与自发性高血压大鼠的血压升高有关。

Acetylcholine in the posterior hypothalamic nucleus is involved in the elevated blood pressure in the spontaneously hypertensive rat.

作者信息

Brezenoff H E, Xiao Y F

机构信息

Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Newark 07103.

出版信息

Life Sci. 1989;45(13):1163-70. doi: 10.1016/0024-3205(89)90504-3.

DOI:10.1016/0024-3205(89)90504-3

PMID:2796602

Abstract

Intravenous injection of physostigmine, 40 and 80 ug/kg, in unanesthetized normotensive rats increased systolic blood pressure (SBP) by 21 +/- 3 and 42 +/- 7 mmHg. This pressor response was 80% inhibited by intracerebroventricular (icv) injection of hemicholinium-3 (HC-3), 20 ug. Simultaneous icv injection of HC-3 and choline (365 ug) prevented the inhibition of the pressor response by HC-3. In spontaneously hypertensive rats, injection of HC-3 either icv (20 ug) or bilaterally into the posterior hypothalamic nuclei (1 ug) decreased SBP by about 40 mmHg. The effect of intrahypothalamic HC-3 was completely blocked by simultaneous injection of choline (24.3 ug) into the same site. The hypotensive effect of icv HC-3 was completely blocked by icv choline (243 ug) and was inhibited up to 60% by injections of choline (24.3 ug) into the posterior hypothalamic nuclei.

摘要

在未麻醉的正常血压大鼠中，静脉注射40微克/千克和80微克/千克的毒扁豆碱，可使收缩压（SBP）分别升高21±3毫米汞柱和42±7毫米汞柱。脑室内（icv）注射20微克的3-羟基甲基氯化胆碱（HC-3）可抑制这种升压反应达80%。同时icv注射HC-3和胆碱（365微克）可防止HC-3对升压反应的抑制。在自发性高血压大鼠中，icv注射20微克HC-3或双侧注射到下丘脑后核1微克可使SBP降低约40毫米汞柱。同时在同一部位注射胆碱（24.3微克）可完全阻断下丘脑内HC-3的作用。icv注射胆碱（243微克）可完全阻断icv HC-3的降压作用，而在下丘脑后核注射胆碱（24.3微克）可使其降压作用抑制达60%。