对未麻醉大鼠下丘脑注射毒扁豆碱后的高血压反应。
The hypertensive response to injection of physostigmine into the hypothalamus of the unanesthetized rat.
作者信息
Buccafusco J J, Brezenoff H E
出版信息
Clin Exp Hypertens (1978). 1978;1(2):219-27. doi: 10.3109/10641967809068605.
PMID:755649
Abstract
Microinjection of physostigmine (3-30 nmoles) into the posterior hypothalamic nucleus of freely-moving, unanesthetized rats elicited a dose-related hypertensive response. This effect was significantly reduced by prior central injection of hemicholinium-3. The direct acting cholinergic agonist, carbachol, also evoked an elevation of blood pressure following intrahypothalamic injection; however, this response was unaffected by prior administration of hemicholinium-3.
摘要
向自由活动、未麻醉大鼠的下丘脑后核微量注射毒扁豆碱（3 - 30纳摩尔）会引发剂量相关的高血压反应。预先向中枢注射3 - 羟甲基胆碱可显著降低这种效应。直接作用的胆碱能激动剂卡巴胆碱在下丘脑内注射后也会引起血压升高；然而，这种反应不受预先给予3 - 羟甲基胆碱的影响。
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