Sheinbergas M M, Verikene V V, Maslinskas V Y, Lyubetsky V B
Acta Virol. 1978 May;22(3):218-24.
In postnatally acquired lymphocytic choriomeningitis (LCM), specific immunofluorescent (IF) IgM antibody was found nearly in all the examined sera from 23 patients for 6-8 months after onset of the disease, IgA antibody in two-thirds of the patients and only during the first 5 weeks of the disease. In the first weeks, the titres of IF IgG and IgM antibodies reached values from 256-512 in some patients; IgA antibody titres were considerably lower. No specific IF IgM and IgA antibody was found in sera from 5 infants with prenatal LCM virus infection (3 infants with congenital hydrocephalus and chorioretinitis, 1 with cerebral palsy and chorioretinitis, and 1 with asymptomatic infection). IF IgM antibody in a titre of 4 was detected only in 2 specimens of the cerebrospinal fluid from one of the infants with hydrocephalus. It is suggested that in prenatal LCM virus infection the production of specific IgM antibody is more or less inhibited.
在产后获得性淋巴细胞性脉络丛脑膜炎（LCM）中，在疾病发作后6 - 8个月，几乎在所有23例患者的检测血清中都发现了特异性免疫荧光（IF）IgM抗体，三分之二的患者在疾病发作后的前5周内发现了IgA抗体。在最初几周，部分患者的IF IgG和IgM抗体滴度达到256 - 512；IgA抗体滴度则低得多。在5例产前感染LCM病毒的婴儿（3例患有先天性脑积水和脉络膜视网膜炎，1例患有脑瘫和脉络膜视网膜炎，1例为无症状感染）的血清中未发现特异性IF IgM和IgA抗体。仅在1例患有脑积水的婴儿的2份脑脊液标本中检测到滴度为4的IF IgM抗体。提示在产前LCM病毒感染中，特异性IgM抗体的产生或多或少受到抑制。
