Szarvas Z, Balogh I, Zsolnai B, Gouth J, Hidvégi J
Morphol Igazsagugyi Orv Sz. 1989 Jul;29(3):171-7.
Authors have applied Danazol-treatment to 15 sexually mature patients because of beningn, menorrhagic bleeding disturbances. Three months after daily 400 to 600 mg Danazol an amenorrhea ensued. Steroid determinations during drug administration were complemented by endometrial biopsy in the amenorrheal state. Samples were studied light and electron microscopically. Upon Danazol-treatment the endometrium showed a patterns resembling that in atrophy or in early proliferations stage of the menstrual cycle. This corresponded to estrogen values obtained. In 3 out of 15 cases the pseudosecretory transformation of the endometrium was observed which is explained by the interaction between Danazol and progesterone receptors.
作者对15名性成熟患者因良性月经过多出血紊乱应用了达那唑治疗。每日服用400至600毫克达那唑三个月后出现闭经。在给药期间进行类固醇测定，并在闭经状态下进行子宫内膜活检作为补充。对样本进行了光镜和电镜研究。接受达那唑治疗后，子宫内膜呈现出类似于萎缩或月经周期早期增殖期的模式。这与所获得的雌激素值相符。在15例病例中有3例观察到子宫内膜的假分泌转化，这是由达那唑与孕酮受体之间的相互作用所解释的。
