Bulletti C, Jasonni V M, Tabanelli S, Balducci M, Fuschini G, Flamigni C
Department of Obstetrics and Gynecology, University of Bologna.
Acta Eur Fertil. 1987 May-Jun;18(3):185-7.
Danazol, an isoxazol derivate of ethinyltestosterone, was used in the treatment of thirtyone postmenopausal patients with endometrial hyperplasia at the dose of 400 mg/day for three months. A profound growth-inhibitory effect of danazol on human endometrium was previously suggested. The present study shows that this compound is effective to reverse the endometrial hyperplasia to normal endometrium in 97% of cases. Atrophic changes of endometrial hyperplasia to normal endometrium after danazol-treatment were observed in 68% of patients. These results strongly suggest that danazol has a significant antiproliferative effect on the endometrium.
达那唑是乙炔睾酮的异恶唑衍生物，以每日400毫克的剂量用于治疗31名绝经后子宫内膜增生患者，疗程为三个月。此前有研究表明达那唑对人子宫内膜有显著的生长抑制作用。本研究表明，该化合物在97%的病例中可有效将子宫内膜增生逆转至正常子宫内膜。68%的患者在接受达那唑治疗后，子宫内膜增生出现萎缩性变化并恢复至正常子宫内膜。这些结果有力地表明，达那唑对子宫内膜具有显著的抗增殖作用。
