Behling R W, Tubbs H K, Cockman M D, Jelinski L W
AT&T Bell Laboratories, Murray Hill, New Jersey 07974.
Nature. 1989 Sep 28;341(6240):321-3. doi: 10.1038/341321a0.
The non-invasive measurement of vascular dynamics and elasticity is critical in understanding haemodynamic conditions of cardiovascular diseases such as hypertension and atherosclerosis. Although there are numerous invasive and in vitro techniques for such measurements, until now non-invasive methods have been limited. We have now obtained stroboscopic NMR images of the carotid arteries of 80-g rats. The change in the cross-sectional area of arteries of diameter approximately 600-800 microns was correlated with the change in absolute blood pressure. These are the first microimages of a dynamic system and enable the direct visualization of compliance, the non-invasive measurement of Young's modulus, the direct determination of the local effects of vasoconstrictors and vasodilators and the mapping of the entire cardiac cycle.
血管动力学和弹性的非侵入性测量对于理解诸如高血压和动脉粥样硬化等心血管疾病的血流动力学状况至关重要。尽管有许多用于此类测量的侵入性技术和体外技术，但到目前为止，非侵入性方法一直很有限。我们现已获得了80克大鼠颈动脉的频闪核磁共振图像。直径约600 - 800微米的动脉横截面积变化与绝对血压变化相关。这些是动态系统的首批微观图像，能够直接观察顺应性、非侵入性测量杨氏模量、直接测定血管收缩剂和血管扩张剂的局部效应以及绘制整个心动周期图。
