Adang R P, Breed W P
Ned Tijdschr Geneeskd. 1989 Jul 29;133(30):1515-8.
A man aged 57 years with a chronic megakaryocytic granulocytic myelosis, treated with an intermittent low-dose busulfan schedule, developed intrahepatic cholestasis. We advise to do liver biopsy, if possible, to differentiate between busulfan hepatotoxicity and leukaemic activity. In the former case, it may be necessary to stop busulfan.
一名57岁患有慢性巨核细胞粒细胞性骨髓增生症的男性，采用间歇性低剂量白消安方案进行治疗，出现了肝内胆汁淤积。我们建议，如有可能，进行肝活检，以区分白消安肝毒性和白血病活性。在前一种情况下，可能有必要停用白消安。
