Morris L E, Guthrie T H
Medical College of Georgia, Augusta.
Am J Gastroenterol. 1988 Jun;83(6):682-3.
A 61-yr-old man with chronic myelocytic leukemia treated continuously for 8 yr with busulfan presented with fever, abdominal pain, and elevated liver enzymes in a cholestatic pattern. Evaluation of his liver and biliary tract with ultrasound and computerized tomography disclosed no structural abnormality. A percutaneous needle liver biopsy revealed cellular cholestasis with focal liver cell necrosis accompanied by a mild inflammatory infiltrate. Busulfan was discontinued, with subsequent normalization of liver enzymes and resolution of fever. These findings are interpreted as being compatible with busulfan-induced hepatitis.
一名61岁的慢性粒细胞白血病男性患者，连续8年使用白消安进行治疗，现出现发热、腹痛以及胆汁淤积型肝酶升高。通过超声和计算机断层扫描对其肝脏和胆道进行评估，未发现结构异常。经皮肝穿刺活检显示细胞性胆汁淤积，伴有局灶性肝细胞坏死，并伴有轻度炎症浸润。停用白消安后，肝酶随后恢复正常，发热症状消退。这些发现被解释为与白消安诱导的肝炎相符。
