Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, CanadaM5S 3M2.
Nanoscale. 2017 Jan 26;9(4):1334-1355. doi: 10.1039/c6nr08486a.
Polymer-lipid hybrid nanoparticles (PLN) are an emerging nanocarrier platform made from building blocks of polymers and lipids. PLN integrate the advantages of biomimetic lipid-based nanoparticles (i.e. solid lipid nanoparticles and liposomes) and biocompatible polymeric nanoparticles. PLN are constructed from diverse polymers and lipids and their numerous combinations, which imparts PLN with great versatility for delivering drugs of various properties to their nanoscale targets. PLN can be classified into two types based on their hybrid nanoscopic structure and assembly methods: Type-I monolithic matrix and Type-II core-shell systems. This article reviews the history of PLN development, types of PLN, lipid and polymer candidates, fabrication methods, and unique properties of PLN. The applications of PLN in delivery of therapeutic or imaging agents alone or in combination for cancer treatment are summarized and illustrated with examples. Important considerations for the rational design of PLN for advanced nanoscale drug delivery are discussed, including selection of excipients, synthesis processes governing formulation parameters, optimization of nanoparticle properties, improvement of particle surface functionality to overcome macroscopic, microscopic and cellular biological barriers. Future directions and potential clinical translation of PLN are also suggested.
聚合物-脂质杂化纳米粒子 (PLN) 是一种新兴的纳米载体平台，由聚合物和脂质构建块组成。PLN 集成了仿生脂质纳米粒子（即固体脂质纳米粒子和脂质体）和生物相容性聚合物纳米粒子的优点。PLN 由多种聚合物和脂质及其众多组合构成，这使其具有将各种性质的药物递送到其纳米级靶标的多功能性。根据其杂化纳米结构和组装方法，PLN 可分为两类：I 型整体基质和 II 型核壳系统。本文综述了 PLN 的发展历史、PLN 的类型、脂质和聚合物候选物、制备方法以及 PLN 的独特性质。总结了 PLN 在单独或联合递送治疗或成像剂用于癌症治疗的应用，并举例说明。讨论了为先进的纳米级药物递送进行 PLN 合理设计的重要考虑因素，包括赋形剂的选择、决定配方参数的合成工艺、优化纳米粒子性质、改善颗粒表面功能以克服宏观、微观和细胞生物学屏障。还提出了 PLN 的未来发展方向和潜在的临床转化。
