Kato I, Kinouchi H, Imaizumi S, Katakura R, Yoshimoto T
Division of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
No Shinkei Geka. 1989 Sep;17(9):877-81.
A case of cerebral astrocytoma associated with a systematic multiple myeloma is reported. A 76-year-old man was admitted to our hospital because of left hemiparesis. The CT scan revealed a cystic tumor at the right parietal lobe. A serum protein electrophoresis showed a monoclonal peak in the region of gamma-globulin, and examination of bone marrow revealed 15% of atypical plasma cells. After irradiation and chemotherapy, the patient suffered from DIC syndrome and died. Autopsy findings revealed a cerebral astrocytoma and bone marrow infiltration by myeloma cells in the sternum, vertebrae, costae, pelvis, and so on. So we finally diagnosed this case a cerebral astrocytoma with systematic multiple myeloma. In spite of the fact that systematic multiple myeloma is frequently accompanied with cancers at other sites (so called multiple primary cancers), the coexistence of a cerebral astrocytoma and systematic multiple myeloma is extremely rare. Complications of multiple myeloma with other tumors are reviewed.
报告了一例与系统性多发性骨髓瘤相关的脑星形细胞瘤病例。一名76岁男性因左侧偏瘫入院。CT扫描显示右顶叶有一个囊性肿瘤。血清蛋白电泳显示γ球蛋白区域有一个单克隆峰，骨髓检查发现15%的非典型浆细胞。放疗和化疗后，患者出现弥散性血管内凝血综合征并死亡。尸检结果显示脑星形细胞瘤以及胸骨、椎骨、肋骨、骨盆等部位有骨髓瘤细胞的骨髓浸润。因此，我们最终将该病例诊断为伴有系统性多发性骨髓瘤的脑星形细胞瘤。尽管系统性多发性骨髓瘤常伴有其他部位的癌症（所谓的多原发性癌症），但脑星形细胞瘤与系统性多发性骨髓瘤并存极为罕见。本文对多发性骨髓瘤与其他肿瘤的并发症进行了综述。
