[一例与超四倍体染色体异常相关的多发性骨髓瘤（IgG，κ型）]

[A case of multiple myeloma (IgG, k) associated with hypertetraploid chromosomal abnormality].

作者信息

Koyama R, Nagai T, Sasagawa Y, Matsumoto S, Enomoto K, Yamada T

机构信息

Dept. of Internal Medicine, Hokkaido Prefecture Sapporo Kitano Hospital.

出版信息

Gan No Rinsho. 1988 Feb;34(2):238-43.

PMID:3126334

Abstract

A patient with multiple myeloma (IgG, k) associated with hypertetraploid chromosomal abnormality is reported. The patient was a 62-year-old female. She was admitted to our clinic in October 6, 1982 because of lumbago and a supraorbital subcutaneous tumor. Cellulose acetate membrane electrophoresis of her serum disclosed a M-protein in the gamma-globulin, and immunoelectrophoresis showed monoclonal IgG, k type. A marrow aspirate of her sternum contained 15% myeloma cells, some of which were large, while others were atypical. A chromosomal analysis of her bone marrow revealed 34 hypertetraploid cells of 35 metaphase cells. Chemotherapy was administered without success and she died of DIC and uremia on November 11, 1982. Histologically, pleomorphic myeloma cells that contained large cells with atypical nuclei proliferated in her bone marrow.

摘要

报告了一例伴有超四倍体染色体异常的多发性骨髓瘤（IgG，κ型）患者。该患者为62岁女性。她于1982年10月6日因腰痛和眶上皮下肿瘤入住我院。其血清醋酸纤维素膜电泳显示γ球蛋白区有M蛋白，免疫电泳显示为单克隆IgG，κ型。胸骨骨髓穿刺显示15%的骨髓瘤细胞，其中一些细胞较大，另一些细胞形态异常。对其骨髓进行染色体分析，在35个中期细胞中有34个超四倍体细胞。给予化疗但未成功，她于1982年11月11日死于弥散性血管内凝血和尿毒症。组织学检查显示，其骨髓中多形性骨髓瘤细胞增殖，其中包含有非典型核的大细胞。