移动视觉刺激在初级视觉皮层诱发的类休克血流动力学反应。
Shock-like haemodynamic responses induced in the primary visual cortex by moving visual stimuli.
作者信息
Lacy T C, Aquino K M, Robinson P A, Schira M M
机构信息
School of Physics, University of Sydney, New South Wales, Australia
Center for Integrative Brain Function, University of Sydney, New South Wales 2006, Australia.
出版信息
J R Soc Interface. 2016 Dec;13(125). doi: 10.1098/rsif.2016.0576.
It is shown that recently discovered haemodynamic waves can form shock-like fronts when driven by stimuli that excite the cortex in a patch that moves faster than the haemodynamic wave velocity. If stimuli are chosen in order to induce shock-like behaviour, the resulting blood oxygen level-dependent (BOLD) response is enhanced, thereby improving the signal to noise ratio of measurements made with functional magnetic resonance imaging. A spatio-temporal haemodynamic model is extended to calculate the BOLD response and determine the main properties of waves induced by moving stimuli. From this, the optimal conditions for stimulating shock-like responses are determined, and ways of inducing these responses in experiments are demonstrated in a pilot study.
研究表明，最近发现的血液动力学波在由刺激驱动时可形成类似激波的前沿，这些刺激在比血液动力学波速度更快移动的斑块中激发皮层。如果选择刺激以诱导类似激波的行为，由此产生的血氧水平依赖（BOLD）反应会增强，从而提高功能磁共振成像测量的信噪比。扩展了一个时空血液动力学模型以计算BOLD反应并确定由移动刺激诱导的波的主要特性。据此，确定了刺激类似激波反应的最佳条件，并在一项初步研究中展示了在实验中诱导这些反应的方法。
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