Cristea I, Popa C
Neurologic Clinic, National Institute of Neurology and Cerebrovascular Diseases, Bucharest, Romania; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Romanian Society of Stroke; Neurology Department, National Institute of Neurology and Cerebrovascular Diseases, Bucharest, Romania.
J Med Life. 2016 Jul-Sep;9(3):270-274.
The study aimed to evaluate the correlations between the clinical and paraclinical data in the lateral bulbar infarction, benefiting from the access to the semiologic characteristics of a group studied and the MRI angiography, without a contrast agent, through the 3D TOF technique combined with MIP, as an imaging technique for the evaluation of the arterial lesion. The study group included 20 patients with lateral bulbar infarction, 14 men, and 6 women aged between 21 and 80 years, the mean age being 56, 9 years, who were enrolled in the study in the period 2012 and 2014, following the admission in the National Institute of Neurology and Neurovascular Diseases. All the patients enrolled in this stage study, performed brain MRI - in the Medinst laboratory, which included the following sequences T1, T2, Flair, DWI, MRI angiography without contrast agent (3D TOF combined with MIP). The study was retrospective. Following the analysis of the 3D TOF sequences combined with MIP, it was found that in the group studied, 8 patients had damage at the level of the vertebral artery, 2 at the level of the posterior inferior cerebellar artery and 10 patients presented mixed lesions of both the vertebral artery and of the PICA artery. In terms of the mechanism involved, most of the lateral bulbar infarctions were generated by arterial dissection (9 cases) and 6 cases had atheroma as etiology. Regarding the risk factors, dyslipidemia and smoking predominated in the studied group and the most common signs and symptoms were gait abnormalities, the ataxia of the limbs, dysphonia, and Horner syndrome. 3D TOF = 3D time of flight angiography, MIP = maximum intensity projection, MRI = magnetic resonance imaging, CT = computed tomography, FLAIR = fluid attenuated inversion recovery, DWI = diffusion weighted imaging, HTA = hypertension, DZ II = diabetes mellitus, VA = vertebral artery, PICA = posterior inferior cerebellar artery, VG = vertigo, NT = nystagmus, N/ E = nausea/ emesis, DP = dysphagia, PVP = pharyngeal/ vocal cord paresis, HS = Horner syndrome, PTH = pain/ temperature hypesthesia, LA = ipsilateral limb ataxia, GA = Gait ataxia, C-R-F = Cardiovascular risk factors, L = left, R = right.
本研究旨在评估延髓外侧梗死的临床和辅助检查数据之间的相关性,通过3D TOF技术结合MIP(最大密度投影)这一无造影剂的MRI血管造影成像技术来评估动脉病变,从而受益于对一组研究对象的症状学特征的了解。研究组包括20例延髓外侧梗死患者,其中男性14例,女性6例,年龄在21至80岁之间,平均年龄为56.9岁,他们于2012年至2014年期间在国立神经病学和神经血管疾病研究所就诊后纳入本研究。所有纳入该阶段研究的患者均在Medinst实验室进行了脑部MRI检查,包括以下序列:T1、T2、液体衰减反转恢复序列(FLAIR)、扩散加权成像(DWI)、无造影剂的MRI血管造影(3D TOF结合MIP)。本研究为回顾性研究。通过对3D TOF序列结合MIP进行分析,发现研究组中8例患者椎动脉水平有损伤,2例患者小脑后下动脉水平有损伤,10例患者椎动脉和小脑后下动脉均有混合性病变。就所涉及的机制而言,大多数延髓外侧梗死是由动脉夹层引起的(9例),6例病因是动脉粥样硬化。关于危险因素,研究组中血脂异常和吸烟最为常见,最常见的体征和症状是步态异常、肢体共济失调、发音困难和霍纳综合征。3D TOF = 三维时间飞跃血管造影,MIP = 最大密度投影,MRI = 磁共振成像,CT = 计算机断层扫描,FLAIR = 液体衰减反转恢复序列,DWI = 扩散加权成像,HTA = 高血压,DZ II = 糖尿病,VA = 椎动脉,PICA = 小脑后下动脉,VG = 眩晕,NT = 眼球震颤,N/E = 恶心/呕吐,DP = 吞咽困难,PVP = 咽/声带麻痹,HS = 霍纳综合征,PTH = 痛温觉减退,LA = 同侧肢体共济失调,GA = 步态共济失调,C-R-F = 心血管危险因素,L = 左,R = 右。