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儿童肝硬化概述

An Overview of Cirrhosis in Children.

作者信息

Cordova Jonathan, Jericho Hilary, Azzam Ruba K

出版信息

Pediatr Ann. 2016 Dec 1;45(12):e427-e432. doi: 10.3928/19382359-20161117-01.

Abstract

Cirrhosis is the end result of nearly all forms of progressive liver disease. The diffuse hepatic process can be characterized as a state of inflammation progressing to fibrosis and resulting in nodular regeneration, ultimately leading to disorganized liver architecture and function. The underlying etiology of cirrhosis in children may often differ from adults owing to specific disease processes that manifest in childhood, including biliary atresia, galactosemia, and neonatal hepatitis. Although basic management strategies in children are similar to those in adults, the care given to children with cirrhosis must keep the child's growth and development of paramount importance. [Pediatr Ann. 2016;45(12):e427-e432.].

摘要

肝硬化是几乎所有形式的进行性肝病的最终结果。这种弥漫性肝脏病变的特征是炎症状态发展为纤维化并导致结节性再生,最终导致肝脏结构和功能紊乱。由于儿童期出现的特定疾病过程,包括胆道闭锁、半乳糖血症和新生儿肝炎,儿童肝硬化的潜在病因可能常常与成人不同。尽管儿童的基本管理策略与成人相似,但对肝硬化儿童的护理必须将儿童的生长发育放在至关重要的位置。[《儿科年鉴》。2016年;45(12):e427 - e432。]

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