Department of Dermatology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
Department of Plastic and Reconstructive Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
J Eur Acad Dermatol Venereol. 2017 Aug;31(8):1285-1288. doi: 10.1111/jdv.14079. Epub 2017 Jan 24.
Recurrence rates after Mohs micrographic surgery (MMS) for rare cutaneous tumours are poorly defined.
To investigate the recurrence rate after MMS for rare cutaneous tumours at a university centre.
METHODS & MATERIALS: Retrospective review of all rare cutaneous tumours treated with MMS at a large university centre between January 2008 and December 2012. To detect all recurrences, patients were linked to The Nationwide Network and registry of histo- and cytopathology (PALGA).
In total, 80 patients with 80 tumours were included. Tumour types included dermatofibrosarcoma protuberans (27), atypical fibroxanthoma (22), Merkel cell carcinoma (8), microcystic adnexal carcinoma (9), sebaceous carcinoma (6), extramammary Paget's disease (2) and other (6). Mean follow-up time was 3.7 years (standard deviation 1.4) during which two atypical fibroxanthomas recurred (2.5%).
This large case series shows that MMS is an appropriate treatment for rare cutaneous tumours with a recurrence rate less than 3%. Preferably, MMS for rare cutaneous tumours is performed in experienced multidisciplinary centres to further improve the quality of treatment.
Mohs 显微外科手术（MMS）治疗罕见皮肤肿瘤的复发率定义不明确。
调查在大学中心 MMS 治疗罕见皮肤肿瘤的复发率。
对 2008 年 1 月至 2012 年 12 月期间在一家大型大学中心接受 MMS 治疗的所有罕见皮肤肿瘤进行回顾性研究。为了检测所有复发情况，将患者与全国组织学和细胞学病理网络（PALGA）相关联。
共纳入 80 例 80 个肿瘤患者。肿瘤类型包括隆突性皮肤纤维肉瘤（27 例）、非典型纤维黄色瘤（22 例）、默克尔细胞癌（8 例）、微囊性附属器癌（9 例）、皮脂腺癌（6 例）、乳腺外Pagets 病（2 例）和其他（6 例）。平均随访时间为 3.7 年（标准差 1.4），其中 2 例非典型纤维黄色瘤复发（2.5%）。
这项大型病例系列研究表明，MMS 是治疗罕见皮肤肿瘤的一种适当方法，其复发率低于 3%。最好在有经验的多学科中心进行 MMS 治疗罕见皮肤肿瘤，以进一步提高治疗质量。
