Morvay K, Szentléleki K, Török G, Pintér A, Börzsönyi M, Reinhard N, Nagy L, Juhász F
Orv Hetil. 1989 Sep 17;130(38):2033-5.
Experimental operative models were created in order to investigate the role of the bile acids in the development of colon cancer in rats. These techniques changed the concentration of bile acids in different parts of the colon, and the daily fecal total bile acid levels. The relationship between these changes and the development of 1,2-dimethylhydrazin-induced colon cancer was studied. Significantly more tumors than in the control group were found if the daily total bile acid level and the concentration of bile acids in the left subsite of the large bowel was increased. Our results suggest that bile acids, as promoting factors, may play a role in the development of colon cancer in rats.
为了研究胆汁酸在大鼠结肠癌发生过程中的作用，建立了实验性手术模型。这些技术改变了结肠不同部位胆汁酸的浓度以及每日粪便中总胆汁酸水平。研究了这些变化与1,2 - 二甲基肼诱导的结肠癌发生之间的关系。如果大肠左半部分的每日总胆汁酸水平和胆汁酸浓度升高，发现肿瘤数量明显多于对照组。我们的结果表明，胆汁酸作为促癌因素，可能在大鼠结肠癌的发生中起作用。
